Guinea Pig Cheilitis

Guinea Pig Cheilitis

Guinea Pig Cheilitis are characterised as small brown nodules growing around the mouth which are caused by lesions from food stuffs where a Bacterial Infection (Typically Staphylococcus Aureus) has infected the surrounding tissue. There can be other causes like Candida (Yeast Infection). A pox virus has also been found in the UK which reportedly can cause Cheilitis.

It is recommended that culturing (Both Microbial and Fungal Cultures), Cleaning with Mild Antiseptic solution and using a topical and systemic antibiotics safe for Guinea Pigs. Check for Dental Disease and treat if present.

BE SURE to check the mouth for signs of Fungal Infection (Thrush).

Excessive Acidic Food has been found to be a common cause of Cheilitis in Guinea Pigs so it is advisable to look at your Guinea Pigs diet and adjust it accordingly. A list of the common problematic foods include :-

  • Apple’s
  • Tomatoes
  • Oranges
  • Cucumber

Would suggest Bite Size Chunks rather then big pieces as excessive rubbing against the Lips and Mouth cause Acid Burns/Lesions leaving the wound open for infection.

Treatment For A Bacterial Infection

Apply triple Antibiotic Ointment Sparingly twice daily. Ointment contains Antibiotics which are not to be ingested so use very carefully. Daily application may be required to keep the infection from returning. Keep wound as clean as possible.


Guinea Pig Cheilitis is thought to be caused by cuts and abrasions from :-

  • Acidic Fruit
  • Coarse Foodstuffs,
  • Bedding,
  • Sharp Objects in the environment which might allow a staph infection to take hold and spread.
  • Dental Disease and Vitamin C Deficiency may also be linked and contributing factors.

Human Cheilitis is caused by poor diet so insure you Guinea Pig is fed Nutritious Foods with Adequate Vitamin B and Vitamin c. Please see images below which show how Cheilitis is normally seen

Us here at Guineapig-info would like to say a Big Thank You to

Dr Malcolm L Jansen BVSc in New Zealand for supplying us with the images below.

  • Guinea Pig Cheilitis