Guinea Pig Urinary Tract Infection

Guinea Pig Urinary Tract Infection

Guinea Pig Urinary Tract Infection are common as there short legs put them low to the ground where they are more likely to pick up bacteria from wet bedding and droppings.

The most noticeable signs of a UTI are :-

  • Squeaking While Peeing
  • Blood In Urine

Differential Diagnosis (Other Possible Conditions)

  • Pyometra
  • Bladder Stones/Sludge
  • Cystitis
  • Arthritis, Spinal Injury (Pain when Peeing or Passing Droppings)

What will my Vet do to Diagnose this Condition?

  • Your Vet will examine you Guinea Pig and palpate the Lower Abdomen
  • An X-Ray may be taken (Two Views) to rule out Bladder Stones/Sludge
  • Your Vet May take a Urine Sample Or if your Guinea Pig doesn’t urinate may Draw it straight from the Bladder using a needle.
  • If there is no visible blood, the Urine can be screened using a Microscope or other Lab tests for the presence of Blood.
  • A Urine Culture can determine which Antibiotics will be the most effective.


Your Veterinarian will decide the best treatment for your Guinea Pig. The most common treatment for a Urinary Tract Infection will be the following :-

  • Antibiotic (This could be Baytril, Septrin)
  • Pain Relief (Normally given Metacam Cat, Metacam Dog – Which is an Anti-Inflammatory Pain Killer)
  • Cystease (Normally given to help with the Healing Process to the bladder walls)
If your Guinea Pig is suffering from Kidney Issues then Baytril may be used as an alternative

to Septrin (Bactrim) as this may cause further problems with the Kidneys.

Call Your Vet Immediately if Bleeding reoccurs after Antibiotics are Stopped

If your vet did NOT perform an x-ray when the Antibiotics were prescribed make sure that an x-ray is taken. Especially if the previous signs are still present.


Your goal is to keep your Guinea Pig as Dry as possible to prevent illness.

  • Keeping the Bottom hairs of long Haired Guinea Pigs short may help.
  • Change bedding more frequently to assure the risks are reduced.
  • Look into Polyester Fabrics as it is report that Urine can drain through but remain Dry.

Some people invest in Safe Plastic Grid Flooring (Envirotiles) to keep Guinea Pig from direct contact with Urine.

Do Not Use Wire/Metal Flooring as this can cause other complications (eg. Bumble Foot)

Cranberry Juice

If your Guinea Pigs have recurrent UTI’s, try offering Unsweetened Diluted Cranberry Juice. Antibiotics will be needed to cure the Infection but Cranberry juice MAY interfere with its development, cutting the incidence of UTI’s in half.

Use only Unsweetened, Natural Cranberry Juice, Syringe feed or place in water bottle. Change bottle containing juice at least daily (preferably twice daily). Plain Natural Unsweetened Cranberry Juice it will have a bitter taste so you will need to dilute it down with water. Do not use Human Cranberry Drinks Sweetened with Sugars, Apple Juice or Other Juices.

Blood In Urine

Urine sometimes changes to an Orange colour on standing (this may be due to Oxidation Of Porphyrins in the Urine – Also see Urine Discolouration). When your Guinea Pig has blood in its Urine it will be Red Or Pink (If its Diluted) Blood will dry a brownish colour.


Cystease/Cystaid may help protect the lining of the bladder and help with the healing process of the Bladder Wall.

Speak To Your Veterinarian or Rodent Health Advisor (RHA) for more information.